Background. Assessment of endoscopic activity of Crohn�s disease (CD) is of growing importance both in clinical practice and in\nclinical trials. The study aimed to assess which of the endoscopic indices used for evaluation ofmucosal changes correlates with the\ncurrently used clinical indices for determination of disease activity and with the results of histopathological examination. Study.\nA group of 71 patients with CD and 52 individuals without a diagnosis of GI tract disease as a control group were investigated,\nconsidering clinical and histological severity of the disease and the severity of inflammatory changes in the bowel. Evaluation was\nconducted with the use of clinical, endoscopic, and histopathological indices. Endoscopic indices were then correlated with different\nclinical and histopathological indices with the aim of finding the strongest correlations. Results and Conclusions. Correlation\nbetween the clinical disease activity and the severity of endoscopic lesions in CD was shown in this study to be poor. The results\nalso indicate that the optimal endoscopic index used in the diagnostic stage and in the assessment of treatment effects in CD is\nSimple Endoscopic Score for Crohn�s Disease (SES-CD).
Loading....